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Retinal Implants Restore Partial Sight To Three Blind. By Peter Murray



 

A microchip with 1,500 light sensors sits beneath the retina and stimulates neurons which project to the brain’s visual cortex.

The blind really are beginning to see again. After receiving retinal implants in a trial, two people in the UK and one in China – all blind – regained part of their vision. And more good news could be on the way as results from other participants comes to light. But the chip is a bright ray of hope for the estimated 1.5 million worldwide that have retinitis pigmentosa, if not for the 285 million visually impaired.

All of the trial participants were made blind by retinitis pigmentosa in which the light-sensitive rods and cones of the retina deteriorate. British participants Robin Millar and Chris James, whose retinas had not responded to light in over a decade, were able to see immediately after the chip was turned on. Seeing the first flashes of light, James told the BBC, was a “magic moment.” Before receiving the implant neither participant was capable of detecting any light at all. The chip now allows James to distinguish between curves and straight lines. And Millar’s magic moment came when he began detecting light coming in through the windows. Professor Robert MacLaren, of Oxford Eye Hospital who co-led the study with Tim Jackson of King’s College Hospital, said the regained vision was a first for a completely blind Brit.

China scores its own first with Tsang Wu Suet Yun. Like James and Millar, Mrs. Tsang had lost her sight to retinitis pigmetnosa. She had been legally blind for 15 years, barely able to detect light. After receiving the same implant as James and Millar, she was able to read letters projected onto a screen.

The following is 2010 footage of a Finnish man who had regained partial vision after receiving an implant from Retina.

The implants act as a replacement for the lost retinal cells by detecting light and then stimulating neurons which send the signal to the brain. Developed by the world leader in retinal implants, Retina Implant Ag, the devices are tiny microchips 5 mm on each side and a tenth of a mm thick, which are implanted just below the retina. The chip’s surface is covered by a microphotodiode array containing 1,500 light-sensitive units. The light intensity of each point is translated into electrical impulses used to stimulate the underlying neurons. The chip is powered by a wireless power unit connected via a cable that runs over the ear and then under the skin to reach the eye. Settings on the power unit can be adjusted to modify the light sensitivity of the array and maximize its effectiveness for individual patients.

The brain needs a period of time to learn how to interpret the “unnatural” signals sent from the chip.

The implant has been involved in retinal trials for six years now, and the current encouraging results could be just the beginning. Results from the first two trials were published in 2010 and prompted the expansion of the trial to sites outside of Germany, including the UK and China.

Being able to distinguish between straight and curved lines or detecting light through a window may not sound like much but, as Prof. MacLaren points out, just being able to enter a room and know where the doors and tables would be is incredibly useful to a blind person. The vibrant colors of the world, however, will remain hidden for the moment. As the implants only convey light contrast they only see in black-and-white. But one unexpected development that’s as much a benefit to Millar as it is a neuroscience curiosity, he’s dreaming in color for the first time in 25 years.

It’s hard to tell without a direct comparison, but Retina’s chip has the potential to out-see the Argus II implant that is already commercially available and helping the blind to see. The Argus II chip doesn’t receive light directly, but relays signals from a glasses-mounted camera. And the chip only has about 60 electrodes with which to stimulate optic nerves and transmit the signal to the brain. Retina’s 1,500 adjustable, light sensing/nerve stimulating units could potentially work so much better.

To reiterate, the current results are part of a clinical trial and the chip is not yet available as a treatment. Replacing dead or non-functional cells with new ones through stem cell therapies would be the ideal treatment. While these therapies have shown great promise recently, there’s no telling just when they’ll deliver on restoring full vision to the blind, if ever. But the results from the current trial are just getting underway. Hopefully it will be more of the same.

[image credits: Retina Implant Ag and Proceedings of The Royal Society]
[video credit: Channel 4 News via YouTube]
images: Retina Implant AgRoyal Society
video: Retinal Implant Ag

The Dangerously Clean Water. By Charles Fishman

The ultra-pure water used to clean semiconductors and make microchips would suck vital minerals right out of your body. Plus it tastes really nasty.

iPhone water

FACT: Water can be too clean to drink—so clean that it’s actually not safe to drink.

That’s the kind of claim about water that people scoff at—it seems ridiculous on the face of it.

Water too clean to drink?

Give me a break. It’s water. Cleaner is better.

But this is one wild water story that’s true.

Every day, around the world, tens of millions of gallons of the cleanest water possible are created, water so clean that it is regarded as an industrial solvent, absolutely central to high-tech manufacturing but not safe for human consumption.

The clean water—it’s called ultra-pure water (UPW)—is a central part of making semiconductors, the wafers from which computer microchips are cut for everything from MRI scanners to greeting cards.

Chips and their pathways are built up in layers, and between manufacturing steps, they need to be washed clean of the solvents and debris from the layer just completed.

But the electronic pathways on microchips are now so fine they can’t be seen even with ordinary microscopes. The pathways are narrower than the wavelengths of visible light. They can only be seen with electron microscopes. And so even the absolute tiniest of debris can be like a boulder on a semiconductor—so the chips have to be washed, but with water that is itself absolutely clean.

The water must have nothing in it except water molecules—not only no specks of dirt or random ions, no salts or minerals, it can’t have any particles of any kind, not even minuscule parts of cells or viruses.

And so every microchip factory has a smaller factory inside that manufactures ultra-pure water. The ordinary person thinks of reverse-osmosis as taking “everything” out of water. RO is the process you use to turn ocean water into crystalline drinking water. And in human terms, RO does take most everything out of the water.

But for semiconductors, RO water isn’t even close. Ultra-pure water requires 12 filtration steps beyond RO. (For those of a technical bent, the final filter in making UPW has pores that are 20 nanometers wide. At the IBM semiconductor plant I visited, they send the 20 nm filters out to be inspected by a private company, using a scanning electron microscope. They want that company to find filters with nothing in them.)

Just the one IBM microchip plant in Burlington, Vermont, makes 2 million gallons of UPW a day for use in manufacturing semiconductors, and there are dozens of chip plants around the world. UPW is also used in pharmaceutical manufacturing, but it is a purely human form of water—water that is literally nothing like the stuff that exists naturally on Earth.

Water is a good cleaner because it is a good solvent—the so-called “universal solvent,” excellent at dissolving all kinds of things. UPW is particularly “hungry,” in solvent terms, because it starts so clean. That’s why it is so valuable for washing semiconductors.

It’s also why it’s not safe to drink. A single glass of UPW wouldn’t hurt you. But even that one glass of water would instantly start leeching valuable minerals back out of your body.

At the chip plants, the staff comes to regard UPW as just another part of a high-tech manufacturing process. One senior IBM official was stunned when I asked her what UPW tasted like. Despite presiding for years over the water purification process, she not only had never tasted it, it has never even occurred to her to taste it. One of her deputies had, though, and he piped right up. “I stuck my tongue in it,” he said. “It was horrid.”

In fact, super-clean water tastes flat, heavy, and bitter. The opposite of what we like. The appealing freshness in water comes not just from it’s temperature and its appearance, but from a sprinkling of salts and minerals that give it a crisp taste.

So there it is: Not only is it possible for water to be too clean to drink—it’s exactly that kind of water that makes your iPhone possible.

Adapted from The Big Thirst: The Secret Life and Turbulent Future of Water, to be published in April by Free Press / Simon & Schuster. © 2011, Charles Fishman.

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